Results
| PMID | 17292896 |
| Gene Name | IL1RN |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 118 |
| Population details | 118 patients underwent laparoscopy for benign gynecologic diseases |
| Sex | Female |
| Associated genes | IL-1ra |
| Other associated phenotypes |
Endometriosis, disease-related dysmenorrhea |
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Fertil Steril. 2007 Sep;88(3):594-9. Epub 2007 Feb 12. Zhang, Xinmei| Wen, Jie| Deng, Lin| Lin, Jun Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China. OBJECTIVE: To determine the level of interleukin-1 receptor antagonist (IL-1ra) in peritoneal fluid (PF) and serum in patients with endometriosis. DESIGN: A prospective analytical study. SETTING: University-affiliated obstetrics and gynecology academic training hospital. PATIENT(S): One hundred eighteen patients underwent laparoscopy for benign gynecologic diseases. INTERVENTION(S): Peripheral blood and PF were obtained before and during surgical procedures, and the levels of IL-1ra were measured. MAIN OUTCOME MEASURE(S): The concentrations of IL-1ra in PF and serum were correlated with the presence of endometriosis, disease stage, and the phase of menstrual cycle. RESULT(S): Peritoneal fluid IL-1ra concentrations were significantly lower in patients with endometriosis than in patients without endometriosis. Peritoneal fluid IL-1ra concentrations decreased with the increased severity of endometriosis and also decreased in disease-related dysmenorrhea; serum IL-1ra levels showed no significant difference between the patients with and without endometriosis. The concentrations of IL-1ra in PF and serum were not correlated with the phase of menstrual cycle. CONCLUSION(S): Our results suggested that decreased levels of PF IL-1ra in patients with endometriosis and disease-related dysmenorrhea may play an important role in the pathogenesis of this disease. Mesh Terms: Abortion, Spontaneous/epidemiology| Adult| Dysmenorrhea/*pathology| Endometriosis/*pathology| Female| Humans| Interleukin 1 Receptor Antagonist Protein/*metabolism| Interleukin-1beta/metabolism| Pregnancy| Sterilization, Tubal|DA 2007/09/26 09:00 |
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